2-HBA

Description: 2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. Target: Caspase, NADPH. Smiles: Oc1ccccc1\C=C\C(=O)\C=C\c1ccccc1O. References: Dinkova-Kostova A T , Cory A H , Bozak R E , et al. Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway[J]. Cancer Letters, 2007, 245(1-2):0-349.