2-deoxy-D-Glucose-13C6

2-deoxy-D-Glucose-13C6 is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose (Cay-14325) by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis. It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate. 2-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml. In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin (Cay-15007) or paclitaxel (Cay-10461).Formal Name: (4R,5S,6R)-6-(hydroxymethyl-13C)tetrahydro-2H-pyran-2,4,5-triol-2,3,4,5,6-13C5. Synonyms: 2-DG-13C6. Molecular Formula: [13C]6H8O5. Formula Weight: 170.1. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Water: soluble. SMILES: O[13CH2][13C@H]1O[13CH]([13CH2][13C@H]([13C@@H]1O)O)O. InChi Code: InChI=1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6+/m1/s1/i1+1,2+1,3+1,4+1,5+1,6+1. InChi Key: PMMURAAUARKVCB-WDZLTIQUSA-N.