2-Chloroadenosine 5-triphosphate (sodium salt)

2-Chloroadenosine 5-triphosphate (2-chloro ATP) is an adenine nucleotide and analog of ATP (Cay-14498). It is an antagonist of the purinergic P2Y1 receptor, inhibiting intracellular calcium mobilization induced by ADP (Cay-21121) in Jurkat cells expressing the human receptor (Ki = 2.3 µM). 2-chloro ATP is an agonist of purinergic P2X receptors, inducing inward currents in HEK293 cells expressing the human bladder smooth muscle or rat PC12 forms of the receptor (EC50s = 0.5 and 2.5 µM, respectively). It induces relaxation of precontracted isolated guinea pig taenia caeci strips in a concentration-dependent manner. It has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases, such as protein kinase A (PKA) and PKG.Formal Name: 2-chloro-adenosine 5'-(tetrahydrogen triphosphate), tetrasodium salt. CAS Number: 301334-89-4. Synonyms: 2-chloro ATP. Molecular Formula: C10H11ClN5O13P3 . 4Na. Formula Weight: 629.6. Purity: >95%. Formulation: (Request formulation change), A solution in water. Solubility: Water: soluble. SMILES: O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)([H])N2C3=NC(Cl)=NC(N)=C3N=C2.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C10H15ClN5O13P3.4Na/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21,,,,/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21),,,,/q,4*+1/p-4/t3-,5-,6-,9-,,,,/m1..../s1. InChi Key: JGKMWMQAWOVZHJ-ZVQJTLEUSA-J.