2',3',5'-Triacetyluridine

2',3',5'-Triacetyluridine is a prodrug of uridine (Cay-20300). It is more lipid soluble than uridine and resistant to degradation by uridine phosphorylase. It is cleaved by plasma esterases in vivo to release uridine. 2',3',5'-Triacetyluridine (6% in the diet) decreases neurodegeneration in the piriform cortex and striatum, as well as reduces the amount of huntingtin-positive aggregates and increases BDNF protein levels in the piriform cortex in a transgenic mouse model of Huntington's disease. It also improves rotarod performance and increases survival in transgenic mouse models of Huntington's disease. 2',3',5'-Triacetyluridine reverses toxicity and increases survival in a mouse model of dihydropyrimidine dehydrogenase (DPD) deficiency-induced 5-fluorouracil (5-FU, Cay-14416) overdose when used at a concentration of 2,000 mg/kg three times per day beginning within 24 hours of 5-FU administration. Formulations containing 2',3',5'-triacetyluridine have been used in the treatment of hereditary orotic aciduria and of overdose or life-threatening toxicity due to flurouracil or capecitabine.Formal Name: 2',3',5'-triacetate uridine. CAS Number: 4105-38-8. Synonyms: PN401, RG2133, 2',3',5'-Tri-O-acetyluridine, Uridine Triacetate. Molecular Formula: C15H18N2O9. Formula Weight: 370.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 257 nm. SMILES: O=C(NC(C=C1)=O)N1[C@H]2[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O2. InChi Code: InChI=1S/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22)/t10-,12-,13-,14-/m1/s1. InChi Key: AUFUWRKPQLGTGF-FMKGYKFTSA-N.