2',2'-Difluoro-2'-deoxyuridine

2',2'-Difluoro-2'-deoxyuridine is an active metabolite of the anticancer nucleoside analog gemcitabine (Cay-11690). It is formed by deamination of gemcitabine by cytidine deaminase in the liver. 2',2'-Difluoro-2'-deoxyuridine is cytotoxic to HepG2 and A549 cancer cells (IC50s = 3.13 and 3.92 µM, respectively). It enhances radiation-induced cell death of ECV304 and NCI H292 cells when used at concentrations ranging from 10 to 100 µM.Formal Name: 2'-deoxy-2',2'-difluoro-uridine. CAS Number: 114248-23-6. Synonyms: dFdU. Molecular Formula: C9H10F2N2O5. Formula Weight: 264.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 258 nm. SMILES: O=C(N(C=C1)[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2)NC1=O. InChi Code: InChI=1S/C9H10F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h1-2,4,6-7,14,16H,3H2,(H,12,15,17)/t4-,6-,7-/m1/s1. InChi Key: FIRDBEQIJQERSE-QPPQHZFASA-N.