18beta-Glycyrrhetinic Acid

18beta-Glycyrrhetinic acid is a major metabolite of glycyrrhizin (Cay-11847), one of the main constituents of licorice. Both 18beta-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit anti-ulcerative, anti-inflammatory, and immunomodulatory properties. 18beta-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC50 = 35 µM). At 100 mg/kg/day, 18beta-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats. 18beta-Glycyrrhetinic acid inhibits mammalian DNA polymerases alpha, gamma, kappa, and lambda with IC50 values of 16.1, 19.3, 15.8, and 13.7 µM, respectively. At 100-200 µM, 18beta-glycyrrhetinic acid suppresses LPS-induced TNF-alpha production and NF-kappaB activation in mouse macrophages.Formal Name: (20beta)-3beta-hydroxy-11-oxo-olean-12-en-29-oic acid. CAS Number: 471-53-4. Synonyms: Arthrodont, Biosone, Enoxolone, alpha-Glycyrrhetinic Acid, GM 1658, NSC 35347, PO 12, STX 352. Molecular Formula: C30H46O4. Formula Weight: 470.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 13 mg/ml, DMSO: 16 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH7.2) (1:7): 0.13 mg/ml. lambdamax: 248 nm. SMILES: CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])CC[C@]([C@@](CC[C@]3(C)[C@@]4([H])C[C@@](C)(C(O)=O)CC3)(C)C4=C5)(C)[C@]2([H])C5=O. InChi Code: InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27?,28-,29+,30+/m0/s1. InChi Key: MPDGHEJMBKOTSU-XVTPHDEKSA-N. Origin: Plant/Glycyrrhiza glabra.