1400W (hydrochloride)

1400W is a potent, selective inhibitor of iNOS. Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively. In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS. In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.Formal Name: N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride. CAS Number: 214358-33-5. Molecular Formula: C10H15N3 . 2HCl. Formula Weight: 250.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: C/C(N([H])CC1=CC(CN)=CC=C1)=N\[H].Cl.Cl. InChi Code: InChI=1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11,,/h2-5H,6-7,11H2,1H3,(H2,12,13),2*1H. InChi Key: WDJHSQZCZGPGAA-UHFFFAOYSA-N.