14(S)-HDHA

Description: Docosahexaenoic acid is a nutritionally-derived omega-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer. 14(S)-HDHA is an oxygenation product of DHA that serves as a precursor to maresin 1 , an anti-inflammatory, pro-resolving mediator that prevents polymorphonuclear neutrophil (PMN) infiltration and stimulates macrophage phagocytosis. At doses as low as 0.2 ng/mouse 14(S)-HDHA administration resulted in reduced infiltration of PMNs into sites of inflammation. Target: Others. Smiles: C(\[C@H](C/C=C\C/C=C\CC)O)=C/C=C\C/C=C\C/C=C\CCC(O)=O