1-Methylnicotinamide (chloride)

Nicotinamide is a precursor of NAD (Cay-16077) and NADP (Cay-10004675), which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT, Cay-15138). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.Formal Name: 3-(aminocarbonyl)-1-methyl-pyridinium, monochloride. CAS Number: 1005-24-9. Synonyms: N1-Methylnicotinamide chloride, Nicotinamide methochloride, Trigonellamide chloride. Molecular Formula: C7H9N2O . Cl. Formula Weight: 172.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 266 nm. SMILES: NC(C1=CC=C[N+](C)=C1)=O.[Cl-]. InChi Code: InChI=1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10,/h2-5H,1H3,(H-,8,10),1H. InChi Key: BWVDQVQUNNBTLK-UHFFFAOYSA-N.