1-methyl-L-Tryptophan

1-methyl-L-Tryptophan is an inhibitor of indoleamine 2,3-dioxygenase (IDO, Ki = 19 µM). It inhibits kynurenine production from primary human monocyte-derived IDO-positive dendritic cells and increases T cell proliferation in an allogeneic mixed lymphocyte reaction (allo-MLR) when used at a concentration of 100 µM. 1-methyl-L-Tryptophan reverses depressive-like behavior in mice in a Bacillus Calmette-Guerin inflammation-induced model of depression. Unlike 1-methyl-D-tryptophan, 1-methyl-L-tryptophan does not have an additive effect on survival induced by cyclophosphamide (Cay-13849) in an orthotopic murine mammary carcinoma model of 4T1 tumors when administered at a dose of 400 mg/kg twice per day.CAS Number: 21339-55-9. Synonyms: NSC 77678, L-1-Methyltryptophan, 1-L-MT, L-1MT. Molecular Formula: C12H14N2O2. Formula Weight: 218.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Aqueous acid: 10 mg/ml. lambdamax: 223 nm. SMILES: OC([C@@H](N)CC1=CN(C)C2=CC=CC=C12)=O. InChi Code: InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1. InChi Key: ZADWXFSZEAPBJS-JTQLQIEISA-N.