1,4-DPCA

The pro-angiogenic factor HIF-1alpha is targeted for destruction in non-hypoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-alpha prolyl hydroxylase (HIF-PH). Inhibitors of prolyl 4-hydroxylase are potentially useful in controlling excess collagen deposition in pathological fibrosis. 1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase in embryonic chick tendon cells and of collagen hydroxylation in human foreskin fibroblasts with an IC50 value of 3.6 and 2.4 µM, respectively. beta-oxocarboxylic acids such as 1,4-DPCA have also been found to inhibit the asparaginyl-hydroxylase, factor inhibiting HIF (FIH), with an IC50 value of 60 µM.Formal Name: 4,4alpha-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid. CAS Number: 331830-20-7. Synonyms: 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid. Molecular Formula: C13H8N2O3. Formula Weight: 240.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 3 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 216, 242, 261, 280, 317, 332. SMILES: O=C1C2=C(C3=NC=CC=C3C=C2)N([H])C=C1C(O)=O. InChi Code: InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18). InChi Key: XZZHOJONZJQARN-UHFFFAOYSA-N.