Tetracycline (hydrochloride)

Tetracycline is a broad-spectrum antibiotic that prevents bacterial growth by inhibiting protein synthesis. It binds to a single site in the 30S ribosomal subunit which prevents attachment of aminoacyl tRNA to the ribosomal acceptor site. It is used in cell biology as a selective agent in cell culture systems. Tetracycline is toxic to prokaryotic and eukaryotic cells and selects for cells harboring the bacterial tetR gene, which are resistant to the antibiotic.Formal Name: (4S,4aS,5aS,6S,12aS)- 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide, monohydrochloride. CAS Number: 64-75-5. Molecular Formula: C22H24N2O8 . HCl. Formula Weight: 480.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.4 mg/ml, DMSO: 1 mg/ml, PBS (pH 7.2): 3.3 mg/ml. lambdamax: 220, 268, 348, 361 nm. SMILES: O=C1C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@](C3=C(O)[C@@]21O)([H])[C@@](O)(C)C4=CC=CC(O)=C4C3=O.Cl. InChi Code: InChI=1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28,/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30),1H/t9-,10-,15-,21+,22-,/m0./s1. InChi Key: XMEVHPAGJVLHIG-FMZCEJRJSA-N.