Sulfameter

Sulfameter is a long-acting sulfonamide antibiotic. In vitro, it is active against the bacteria D. pneumoniae, K. pneumoniae, E. coli, N. meningitidis, P. vulgaris, S. aureus, S. haemolyticus, and S. typhimurium in a disc assay. Sulfameter is efficacious against lethal K. pneumoniae, E. coli, P. vulgaris, D. pneumoniae, P. aeruginosa, and S. typhimurium infection in a mouse model of septicemia with 50% curative dose (CD50) values of 1.6, 5.2, 5.4, 120.5, 19.1, and 88 mg/kg, respectively. Formulations containing sulfameter have previously been used in the treatment of urinary tract infections.Formal Name: 4-amino-N-(5-methoxy-2-pyrimidinyl)-benzenesulfonamide. CAS Number: 651-06-9. Synonyms: Bayrena, NSC 683528, Sulfamethoxydiazine. Molecular Formula: C11H12N4O3S. Formula Weight: 280.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 20 mg/ml. lambdamax: 214, 230, 272 nm. SMILES: NC1=CC=C(S(NC2=NC=C(OC)C=N2)(=O)=O)C=C1. InChi Code: InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15). InChi Key: GPTONYMQFTZPKC-UHFFFAOYSA-N.