Sulfadimethoxine

Sulfadimethoxine is a sulfonamide antibiotic that is active against Gram-negative and Gram-positive bacteria and other microorganisms. It inhibits recombinant P. carinii dihydropteroate synthase (DHPS, IC50 = 25 nM), an enzyme required for folate biosynthesis, in a cell-free assay. Sulfadimethoxine is active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay. It is also active against C. spiroforme isolates from rabbits (MIC90 = 256 µg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = =256 µg/ml). Sulfadimethoxine is efficacious against S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice with 50% curative dose (CD50) values of 79.7, 2.7, and 12.2 mg/kg, respectively. It is also efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg).Formal Name: 4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)-benzenesulfonamide. CAS Number: 122-11-2. Synonyms: Sulphadimethoxine. Molecular Formula: C12H14N4O4S. Formula Weight: 310.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20mg/mL, DMF:PBS (pH 7.2) (1:7): 0.16mg/mL, DMSO: 10mg/mL. lambdamax: 273 nm. SMILES: COC1=NC(OC)=CC(NS(C2=CC=C(N)C=C2)(=O)=O)=N1. InChi Code: InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16). InChi Key: ZZORFUFYDOWNEF-UHFFFAOYSA-N.