Sancycline (hydrochloride)

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline (Cay-14328) against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 µg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 µg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.Formal Name: (4S,4aS,5aR,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide, monohydrochloride. CAS Number: 6625-20-3. Synonyms: 6-Demethyl-6-deoxytetracycline, NSC 51812. Molecular Formula: C21H22N2O7 . HCl. Formula Weight: 450.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20mg/mL, DMSO: 20mg/mL, DMSO:PBS (pH 7.2) (1:5): 0.15 mg/mL, Ethanol: 5mg/mL. lambdamax: 221, 268, 350 nm. SMILES: O=C1C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@](C3=C(O)[C@@]21O)([H])CC4=CC=CC(O)=C4C3=O.Cl. InChi Code: InChI=1S/C21H22N2O7.ClH/c1-23(2)15-10-7-9-6-8-4-3-5-11(24)12(8)16(25)13(9)18(27)21(10,30)19(28)14(17(15)26)20(22)29,/h3-5,9-10,15,24,26-27,30H,6-7H2,1-2H3,(H2,22,29),1H/t9-,10-,15-,21-,/m0./s1. InChi Key: NHHHLWBNBLFCSB-QKYUADJBSA-N.