Sancycline

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 µg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 µg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. Product References: (1) J.R.D. McCormick, et al., JACS 82, 3381 (1960) , (2) R.T. Testa, et al., Antimicrob. Agents Chemother. 37, 2270 (1993) , (3) H.M. Wexler, et al., Antimicrob. Agents Chemother. 38, 2513 (1994) Appearance: Yellow to green powder. Solubility: Soluble in DMSO. Identity: Determined by 1H-NMR. InChi Key: XDVCLKFLRAWGIT-ADOAZJKMSA-N Smiles: OC1=C2C(C[C@]3([H])C(C2=O)=C(O)[C@@]4(O)[C@@]([C@H](N(C)C)C(O)=C(C(N)=O)C4=O)([H])C3)=CC=C1