Rolitetracycline

Rolitetracycline is a tetracycline antibiotic with bacteriostatic activity at low concentrations (7.8 µg/ml) and bactericidal activity at high concentrations (15.6 µg/ml) against E. coli. It has additive and synergistic effects with penicillin and cephalothin, respectively, in vitro against 34 E. coli and S. aureus strains. Rolitetracycline is also active against P. falciparum strains (IC50s = 45-208 µM) that are susceptible and resistant to chloroquine (Cay-14194). It also reduces amyloid-beta (1-40) (Abeta40) fibrilization (IC50 = 59 µM in an immune assay) and completely inhibits Abeta40-induced cellular toxicity at a concentration of 20 µM.Formal Name: 4-(dimethylamino)-1,4S,4aS,5,5aS,6S,11,12aS-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide. CAS Number: 751-97-3. Synonyms: Pyrrolidinylmethyltetracycline, SQ 15,659. Molecular Formula: C27H33N3O8. Formula Weight: 527.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. lambdamax: 219, 267, 365 nm. SMILES: OC([C@@](C(C(C(NCN1CCCC1)=O)=C(O)[C@H]2N(C)C)=O)(O)[C@@]2([H])C3)=C([C@@]3([H])[C@@]4(O)C)C(C5=C4C=CC=C5O)=O. InChi Code: InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14-,15-,20-,26+,27-/m0/s1. InChi Key: HMEYVGGHISAPJR-IAHYZSEUSA-N.