Rifampicin

Rifampicin is a rifamycin antibiotic and inhibitor of bacterial RNA polymerase (IC50 = 0.01 µg/ml for the E. coli enzyme). It inhibits the growth of M. tuberculosis H37Rv in mouse peritoneal macrophages (MIC = 0.8 µg/ml) as well as clinical isolates of various species of Staphylococcus, Streptococcus, Haemophilus, and Neisseria (MICs = 0.009-1.4 µg/ml). Rifampicin increases survival in a mouse model of tuberculosis infection. It is also an agonist of the human pregnane X receptor (PXR, EC50 = ~2 µM). Formulations containing rifampicin have been used in the treatment of tuberculosis and meningococcal carriers.Formal Name: 3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin. CAS Number: 13292-46-1. Synonyms: NIH 10782, NSC 113926, Rifampin. Molecular Formula: C43H58N4O12. Formula Weight: 823.0. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.50 mg/ml, DMSO: 3.3 mg/ml, Ethanol: 0.12 mg/ml. lambdamax: 236, 339, 479 nm. SMILES: OC1=C2C(C(O)=C(C)C(O[C@]3(C)O/C=C/[C@H](OC)[C@@H](C)[C@]([C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C(C)\C(N4)=O)(OC(C)=O)[H])=C2C3=O)=C(O)C4=C1/C=N/N5CCN(C)CC5. InChi Code: InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2. InChi Key: JQXXHWHPUNPDRT-SBMPKVQQSA-N.