Posaconazole

Posaconazole is a broad-spectrum triazole antifungal agent active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14alpha-demethylase enzyme (IC50s = 7-200 nM), which results in a disruption in the synthesis of ergosterol (Cay-19850), a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.Formal Name: 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol. CAS Number: 171228-49-2. Synonyms: POS, SCH 56592. Molecular Formula: C37H42F2N8O4. Formula Weight: 700.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMSO: 0.5 mg/ml. lambdamax: 263 nm. SMILES: O=C1N([C@H]([C@@H](O)C)CC)N=CN1C(C=C2)=CC=C2N3CCN(C4=CC=C(OC[C@@H]5CO[C@](C6=CC=C(F)C=C6F)(CN7C=NC=N7)C5)C=C4)CC3. InChi Code: InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m. InChi Key: RAGOYPUPXAKGKH-XAKZXMRKSA-N.