Oligomycin E

Oligomycin E is a minor metabolite of the oligomycin complex (Cay-11341) produced by several species of Streptomyces. It exhibits relatively weak antifungal activity compared to other oligomycins, yet is active against Gram-positive bacteria and demonstrates strong antitumor activity against HeLa cells (IC50 = 14 ng/ml).Formal Name: (1R,2'S,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28R,29R)-22-ethyl-5',6'-dihydro-7,11,14,15,28-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,3',9,13(4'H)-tetrone. CAS Number: 110231-34-0. Synonyms: 26-hydroxy-28-oxo-Oligomycin A. Molecular Formula: C45H72O13. Formula Weight: 821.1. Purity: >95%. Formulation: (Request formulation change), A lyophilisate. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: C[C@]1(O)[C@@](C(C[C@@H]2C)=O)(O[C@H]([C@]([H])([C@H]1OC(/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@H](C)C3=O)=O)=O)C)CC[C@@]([H])(CC)/C=C/C=C/C[C@@H](C)[C@H](O)[C@@]3(C)O)O[C@H]2C[C@@H](C)O. InChi Code: InChI=1S/C45H72O13/c1-12-32-17-15-13-14-16-25(3)40(52)43(10,54)41(53)31(9)39(51)30(8)38(50)29(7)37(49)24(2)18-21-36(48)56-42-28(6)33(20-19-32)57-45(44(42,11)55)35(47)22-26(4)34(58-45)23-27(5)46/h13-15,17-18,21,24-34,37,39-40,42,46,49,51-52,54-55H,12,. InChi Key: UWEZMQMMPORRMH-BOCHHXLBSA-N.