Nalidixic Acid

Nalidixic acid is a quinolone antibiotic. It is active against E. coli, Pasturella, K. pneumoniae, A. aerogenes, Proteus, Salmonella, and Shigella with minimum bacteriostatic concentrations (MBCs) ranging from 0.5 to 25 µg/ml. Nalidixic acid increases survival in mouse models of systemic K. pneumoniae, A. aerogenes, Proteus, or Salmonella infection (ED50s = 60, 35, 50, and 62 mg/kg, respectively). Formulations containing nalidixic acid have previously been used in the treatment of urinary tract infections.Formal Name: 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid. CAS Number: 389-08-2. Synonyms: NSC 82174, WIN 18,320. Molecular Formula: C12H12N2O3. Formula Weight: 232.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.5 M NaOH: 50 mg/ml, Acetonitrile: >1 mg/ml. lambdamax: 258, 330 nm. SMILES: CCN1C=C(C(O)=O)C(C2=CC=C(C)N=C21)=O. InChi Code: InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17). InChi Key: MHWLWQUZZRMNGJ-UHFFFAOYSA-N.