Nadifloxacin

Nadifloxacin is a fluoroquinolone antibiotic. It is active against clinical isolates of S. aureus, coagulase-negative staphylococci, P. acnes, and P. granulosum (MIC50s = 0.03, 0.06, 0.25, and 0.125 mg/L, respectively). Nadifloxacin inhibits the activities of DNA gyrase and topoisomerase IV (IC50s = 8.83 and 3.22 mg/L, respectively, for the S. aureus enzymes). Nadifloxacin (30 µg/ml) inhibits P. acnes-induced increases in the production of IFN-gamma, IL-1beta, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs), as well as reduces P. acnes-induced increases in the production of IL-8 and IL-6 in isolated human keratinocytes. Topical application of a cream containing nadifloxacin (1%) reduces the number of skin lesion colony forming units (CFUs) in a mouse model of burn wounds infected with S. aureus or P. acnes. Formulations containing nadifloxacin have been used in the treatment of acne vulgaris.Formal Name: 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid. CAS Number: 124858-35-1. Synonyms: OPC 7251. Molecular Formula: C19H21FN2O4. Formula Weight: 360.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 216, 235, 295, 321 nm. SMILES: O=C1C(C(O)=O)=CN2C3=C(CCC2C)C(N4CCC(O)CC4)=C(F)C=C31. InChi Code: InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26). InChi Key: JYJTVFIEFKZWCJ-UHFFFAOYSA-N.