Lydicamycin

Lydicamycin is an antibiotic first isolated from Streptomyces. It is particularly cytotoxic against S. aureus, including the methicillin resistant 535 strain (MICs = 3.1-6.2 µg/ml). Lydicamycin also inhibits the growth of C. neoformans (MIC = 25 µg/ml) but is ineffective against Gram-negative bacteria.Formal Name: 2-[21-[1-[(2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)carbonyl]-1,2,4a,5,6,7,8,8a-octahydro-5,6-dihydroxy-1,3-dimethyl-2-naphthalenyl]-2,6,10,14,18-pentahydroxy-5,11,17,19-tetramethyl-4,8,12,16-heneicosatetraen-1-yl] 1-pyrrolidinecarboximidamide. CAS Number: 133352-27-9. Synonyms: Antibiotic CC 12. Molecular Formula: C47H74N4O10. Formula Weight: 855.1. Purity: >95%. Formulation: (Request formulation change), A film. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: OC1C(O)C2C(C(C(C3=C(O)CNC3=O)=O)(C)C(CCC(C)C(O)/C(C)=C/CC(/C=C/C(C)C(O)/C=C/CC(O)/C(C)=C/CC(CC4CCCN4C(N)=N)O)O)C(C)=C2)CC1. InChi Code: InChI=1S/C47H74N4O10/c1-26(37(54)10-7-11-38(55)27(2)13-18-33(53)24-31-9-8-22-51(31)46(48)49)12-16-32(52)17-14-28(3)42(58)29(4)15-19-35-30(5)23-34-36(20-21-39(56)43(34)59)47(35,6)44(60)41-40(57)25-50-45(41)61/h7,10,12-14,16,23,26,29,31-39,42-43,52-59H. InChi Key: BCOQUXPMOLQABB-CTAFOSPESA-N. Origin: Bacterium/Streptomyces sp..