Isobavachalcone

Isobavachalcone (IBC) is a chalcone and flavonoid originally isolated from P. corylifolia and has diverse biological activities. It is active against C. albicans and C. neoformans (IC50s = 3 and 7 µg/ml, respectively), as well as T. rubrum and M. audouinii (MIC = 1.2 µg/ml for both). IBC is active against various Bacillus, Streptococcus, and Proteus species, as well as K. pneumoniae, P. aeruginosa, S. typhi, M. morganii, E. aerogenes, C. freundii, and E. cloacae (MICs = 4.9-39.1 µg/ml). It induces mitochondrial-mediated apoptosis in IMR-32 and NB-39 human neuroblastoma cells and inhibits the proliferation of OVCAR-8 ovarian, PC3 prostate, MCF-7 breast, and A549 lung cancer cell lines. IBC (50 mg/kg) reduces dopaminergic neuronal cell death and increases the stay time in the rotarod test in a mouse model of MPTP-induced Parkinson's disease.Formal Name: (2E)-1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one. CAS Number: 20784-50-3. Synonyms: Corylifolinin, IBC. Molecular Formula: C20H20O4. Formula Weight: 324.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, Ethanol: 30 mg/mL, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/mL. lambdamax: 369 nm. SMILES: OC1=CC=C(/C=C/C(C2=C(O)C(C/C=C(C)/C)=C(O)C=C2)=O)C=C1. InChi Code: InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+. InChi Key: DUWPGRAKHMEPCM-IZZDOVSWSA-N.