Hygromycin B (hydrate)

Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 µg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for transformed cells expressing the E. coli hygromycin resistance genes hyg or hph.Formal Name: O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene- (1->2-3)-O-beta-D-talopyranosyl- (1->5)-2-deoxy-N3-methyl-D-streptamine, hydrate. Molecular Formula: C20H37N3O13 . XH2O. Formula Weight: 527.5. Purity: >85%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 3.3 mg/ml, PBS (pH 7.2): 3.3 mg/ml. SMILES: O[C@H]1[C@@H](CO)O[C@@H](O[C@@]2([H])[C@H](O)[C@@H](NC)C[C@@H](N)[C@@H]2O)[C@]3([H])[C@@]1([H])OC4(O[C@@]([C@@H](N)CO)([H])[C@H](O)[C@H](O)[C@H]4O)O3.O. InChi Code: InChI=1S/C20H37N3O13.H2O/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24,/h5-19,23-31H,2-4,21-22H2,1H3,1H2/t5-,6+,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20?,/m1./s1. InChi Key: FOVDUCWCXNHTHM-IGPOGLENSA-N.