Heptelidic acid

Antibiotic - Potent selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GADPH - Anticancer compound. Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation - Antimalarial - Apoptosis inhibitor. DNA fragmentation and caspase-3 activation inhibitor - Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols.