Echinomycin

Echinomycin
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay11049-1 1 mg -

6 - 10 Werktage*

133,00 €
Cay11049-5 5 mg -

6 - 10 Werktage*

491,00 €
 
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in... mehr
Produktinformationen "Echinomycin"
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription. It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1alpha or HIF-1beta to the hypoxia-responsive element. Echinomycin reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50 value of 1.2 nM. It inhibits hypoxia-induced expression of vascular endothelial growth factor, blocking angiogenesis and altering excitatory synaptic transmission in hippocampal neurons. Echinomycin also impairs expression of survivin, enhancing the sensitivity of multiple myeloma cells to melphalan.Formal Name: N-(2-quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-(8->1)-lactone, cyclic (3->7)-thioether-L-valine. CAS Number: 512-64-1. Synonyms: Antibiotic A 654I, NSC 13502, NSC 526417, Quinomycin A, SK 302B. Molecular Formula: C51H64N12O12S2. Formula Weight: 1101.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Methanol: Soluble. lambdamax: 244 nm. SMILES: O=C(NC(COC(C(C(C)C)N(C)C(C1CS2)=O)=O)C(NC(C)C(N(C(C2SC)C(N(C)C(C(OCC(NC(C3=NC(C=CC=C4)=C4N=C3)=O)C(NC(C(N1C)=O)C)=O)=O)C(C)C)=O)C)=O)=O)C5=NC6=C(N=C5)C=CC=C6. InChi Code: InChI=1S/C51H64N12O12S2/c1-25(2)38-49(72)74-22-36(59-42(65)34-21-53-30-17-13-15-19-32(30)57-34)44(67)55-28(6)46(69)63(10)40-48(71)62(9)39(26(3)4)50(73)75-23-35(58-41(64)33-20-52-29-16-12-14-18-31(29)56-33)43(66)54-27(5)45(68)60(7)37(47(70)61(38)8)24-. InChi Key: AUJXLBOHYWTPFV-UHFFFAOYSA-N.
Schlagworte: Antibiotic A 654I, NSC 13502, NSC 526417, Quinomycin A, SK 302B, N-(2-quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-(8->1)-lactone, cycli
Hersteller: Cayman Chemical
Hersteller-Nr: 11049

Eigenschaften

Anwendung: Apoptosis inducer
MW: 1101.3 D
Formel: C51H64N12O12S2
Reinheit: >95%
Format: Crystalline Solid

Datenbank Information

CAS : 512-64-1| Passende Produkte
KEGG ID : K08268 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H301, H311, H331, H361
P-Sätze: P201, P202, P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P308+313, P311, P312, P321, P330, P361+364, P403+233, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Echinomycin"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen