Doxycycline (hyclate)

Doxycycline is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 µM. It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline. Formulations containing doxycycline have been used in the treatment of bacterial infections and the prevention of malaria.Formal Name: (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide, hydrochloride, compd. with ethanol, hydrate (2:2:1:1). CAS Number: 24390-14-5. Molecular Formula: 2[C22H24N2O8] . 2HCl . H2O . C2H6O. Formula Weight: 1025.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 215, 272, 348 nm. SMILES: OC1=C2C([C@H](C)C3C(C2=O)=C(O)[C@@]4(O)C([C@H](N(C)C)C(O)=C(C(N)=O)C4=O)[C@H]3O)=CC=C1.CCO.OC5=C6C([C@H](C)C7C(C6=O)=C(O)[C@@]8(O)C([C@H](N(C)C)C(O)=C(C(N)=O)C8=O)[C@H]7O)=CC=C5.Cl.O.Cl. InChi Code: InChI=1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29,1-2-3,,,/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31),3H,2H2,1H3,2*1H,1H2/t2*7-,10?,14?,15-,17-,22-,,,,/m00.... InChi Key: HALQELOKLVRWRI-ZVACAFRPSA-N.