Cefuroxime (sodium salt)

Cefuroxime is a cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria including S. pyogenes, S. pneumoniae, S. viridans, E. coli, P. mirabilis, H. influenzae, and N. gonorrhoeae (mean MICs = 0.005-8.2 µg/ml). Like other cephalosporins, cefuroxime inhibits peptidoglycan crosslinking and bacterial cell wall synthesis. It is resistant to hydrolysis by bacterial beta-lactamases, increasing its efficacy against beta-lactamase producing Gram-negative bacteria. Cefuroxime is protective against Gram-positive and Gram-negative infections in vivo with mean ED50 values ranging from 2 to 35 and 1 to 55 mg/kg, in mice and rats, respectively. Formulations containing cefuroxime have been used to treat urinary tract infections.Formal Name: (6R,7R)-3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-furanyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt. CAS Number: 56238-63-2. Molecular Formula: C16H15N4O8S . Na. Formula Weight: 446.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: O=C([O-])C1=C(COC(N)=O)CS[C@@]([C@@H]2NC(/C(C3=CC=CO3)=N\OC)=O)([H])N1C2=O.[Na+]. InChi Code: InChI=1S/C16H16N4O8S.Na/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20,/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24),/q,+1/p-1/b19-9-,/t10-,14-,/m1./s1. InChi Key: URDOHUPGIOGTKV-JTBFTWTJSA-M.