Ceftriaxone (sodium salt hydrate)

Ceftriaxone is a cephalosporin antibiotic. It is selectively active against Gram-negative bacteria, including N. gonorrhea and S. pyogenes (MICs = 0.01-0.025 and 0.012-0.25 µg/ml, respectively), over Gram-positive bacteria such as S. epidermidis and S. aureus (MICs = >25 µg/ml for both). Ceftriaxone inhibits S. pyogenes penicillin-binding protein 2 (PBP2) and PBP3 (IC50s = 0.108 and 0.146 µg/ml, respectively). Formulations containing ceftriaxone have been used in the treatment of various bacterial infections.Formal Name: (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt, hemiheptahydrate. CAS Number: 104376-79-6. Synonyms: Ro 13-9904. Molecular Formula: C18H16N8O7S3 . 2Na [3.5H2O]. Formula Weight: 661.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 241 nm. SMILES: O=C(C1NC(/C(C2=CSC(N)=N2)=N\OC)=O)N3[C@]1([H])SCC(CSC(N(C)N=C4[O-])=NC4=O)=C3C([O-])=O.O=C(C5NC(/C(C6=CSC(N)=N6)=N\OC)=O)N7[C@]5([H])SCC(CSC(N(C)N=C8[O-])=NC8=O)=C7C([O-])=O.O.O.O.O.O.O.[Na+].[Na+].O.[Na+].[Na+]. InChi Code: InChI=1S/2C18H18N8O7S3.4Na.7H2O/c2*1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7,,,,,,,,,,,/h2*5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32),,,,,7*1H2/q,,4*+1,,,,,,,/p-4/b2*24-8-,,,,,,,,,,,/t2*9?,15-,,,,,,,,,,,/m11.........../s1. InChi Key: KTAVBOYXMBQFGR-PWCTXUHCSA-J.