Cefalothin (sodium salt)

Cefalothin is a beta-lactam cephalosporin antibiotic. It inhibits the growth of various Gram-positive and Gram-negative bacteria, including several strains of S. pyogenes, S. aureus, C. tetani, N. gonorrhoeae, Salmonella, and Shigella (MICs = 0.1-0.2, 0.312-0.625, 0.078, 1.25, 1.56-6.25, and 3.12-12.5 µg/ml, respectively). Cefalothin binds to E. coli penicillin-binding proteins (PBPs, IC50s = S. pyogenes, D. pneumoniae, and S. aureus. Formulations containing cefalothin were previously used in the prophylaxis and treatment of bacterial infections.Formal Name: (6R)-3-[(acetyloxy)methyl]-8-oxo-7R-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt. CAS Number: 58-71-9. Molecular Formula: C16H15N2O6S2 . Na. Formula Weight: 418.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: O=C(CC1=CC=CS1)N[C@H](C2=O)[C@]3([H])N2C(C([O-])=O)=C(COC(C)=O)CS3.[Na+]. InChi Code: InChI=1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10,/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23),/q,+1/p-1/t12-,15-,/m1./s1. InChi Key: VUFGUVLLDPOSBC-XRZFDKQNSA-M.