Mouse Slc22a7 (Solute carrier family 22 member 7) ELISA Kit

ELISA Type: Sandwich ELISA, Double Antibody. Detection Range: 31.25-2000µg/mL. Sensitivity: 18.75µg/mL. Sample Types: Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples. Protein function: Functions as a Na(+)-independent bidirectional multispecific transporter (PubMed:12065749). Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively (PubMed:12065749). Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides, and nucleotides with cGMP, 2'deoxyguanosine and GMP being the preferred substrates. Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways. Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood. Involved in renal secretion and possible reabsorption of creatinine. Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (Probable). Also transports alpha-ketoglutarate and urate (PubMed:12065749). Unlike human hortolog, able to transport glutarate (PubMed:12065749). Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified. [The UniProt Consortium]