Caspase-1 (mouse) ELISA Kit

Detection Type: Colorimetric. Assay Type: Sandwich 96 well assay. Sample Type: Cell Culture Supernatant. Range: 0.15ng/ml to 10ng/ml. Sensitivity: 33pg/ml. Detects mouse caspase-1 (proform as well as p10 and p20 domain). Does not detect human caspase-1. Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and interleukin-18 (IL-18) and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3/NALP3 responds to a variety of agonists including crystals. This Caspase-1 (mouse) ELISA Kit can be used to measure caspase-1 (mouse) in cell culture supernatants. It is a quantitative detection method, alternative to Western blotting to measure caspase-1 secretion.