Anti-phospho-BRCA1 (Ser1524)

Anti-phospho-BRCA1 (Ser1524)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A300-001A-T 10 µl (10 µg) -

2 - 8 Werktage*

164,00 €
A300-001A 100 µl (100 µg) -

2 - 8 Werktage*

626,00 €
 
Protein function: E3 ubiquitin-protein ligase that specifically mediates the formation of... mehr
Produktinformationen "Anti-phospho-BRCA1 (Ser1524)"
Protein function: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719). [The UniProt Consortium]
Schlagworte: Anti-phospho-BRCA1, Anti-phospho-RNF53, Anti-phospho-RING finger protein 53, Anti-phospho-RING-type E3 ubiquitin transferase BRCA1, Anti-phospho-Breast cancer type 1 susceptibility protein
Hersteller: Bethyl Laboratories
Hersteller-Nr: A300-001A

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human (Erwartet: gorilla, chimpanzee)
Immunogen: synthetic peptide. Immunogen for A300-001A-T was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1524 according to the numbering given in entry NP_009225.1.
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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