Anti-H3K18me1 / Monomethyl Histone H3 Lysine 18, clone RM167 (recombinant antibody)

1 mg/ml in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant H3K18me1 antibody reacts to Histone H3 monomethylated at Lysine 18 (K18me1). No cross reactivity with dimethylated (K18me2) or trimethylated Lysine 18(K18me3), or other methylations in Histone H3. Protein function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [The UniProt Consortium]