Anti-cleaved-ITGA3 (heavy chain, Phe33)

integrin subunit alpha 3(ITGA3) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015], Protein function: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha- 3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000, IF/ICC 1:50-200,ELISA 1:2000-20000,IHC-p 1:50-200. Cellular localization: Cell membrane , Single-pass type I membrane protein . Cell membrane , Lipid-anchor . Cell projection, invadopodium membrane , Single-pass type I membrane protein . Cell projection, filopodium membrane , Single-pass type I membrane protein . Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. .