Anti-ZBTB40

Anti-ZBTB40 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. ZBTB40 antibody is human specific. At least two isoforms of ZBTB40 are known to exist. This antibody is predicted to not cross-react with other ZBTB protein family members. Protein function: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. [The UniProt Consortium]