Anti-Wdr5

Anti-Wdr5 Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. Cross reactivity with Wdr5 from other species not tested. Protein function: Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. [The UniProt Consortium]