Anti-VDAC1 (Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM

The voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane is a small, , abundant outer membrane pore-forming protein found in the outer membranes of all eukaryotic , mitochondria. The VDAC protein is thought to form the major pathway for movement of adenine , nucleotides through the outer membrane and to be the mitochondrial binding site for hexokinase and , glycerol kinase. At low transmembrane voltage, VDAC is open for anions such as phosphate, chloride, , and adenine nucleotides. At higher transmembrane voltage, VDAC functions as a selective channel for , cations and uncharged molecules. These features make VDAC likely to play a role in mitochondrial , energy metabolism. Huizing et al. studied by Northern and Western blot analyses the human tissue , distribution of mitochondrial transmembrane metabolite carriers. They found that VDAC1 mRNA has a , ubiquitous distribution, with most pronounced expression in heart, liver, and skeletal muscle, whereas , the VDAC2 isoform appears to be expressed only in the heart. UniProt Number: P21796, Gene ID: VDAC1, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen), and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.