Anti-USP10

Anti-USP10
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A300-901A-T 10 µl (2 µg) -

2 - 8 Werktage*

164,00 €
A300-901A 100 µl -

2 - 8 Werktage*

588,00 €
 
Protein function: Hydrolase that can remove conjugated ubiquitin from target proteins such as... mehr
Produktinformationen "Anti-USP10"
Protein function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34- containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). [The UniProt Consortium]
Schlagworte: Anti-USP10, Anti-KIAA0190, Anti-Ubiquitin thioesterase 10, Anti-Deubiquitinating enzyme 10, Anti-Ubiquitin carboxyl-terminal hydrolase 10, Anti-Ubiquitin-specific-processing protease 10
Hersteller: Bethyl Laboratories
Hersteller-Nr: A300-901A

Eigenschaften

Anwendung: WB, IP, IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human (Erwartet: orangutan, rhesus monkey, gorilla, chimpanzee, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by A300-901A-T maps to a region between residue 300 and 3500 of human Ubiquitin Specific Peptidase 10 using the numbering given in entry NP_005144.1 (GeneID 9100).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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