Anti-TP53BP1

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABS-OC-258.50 50 µl - -

Fragen Sie uns nach der Lieferzeit

206,00 €
ABS-OC-258.100 100 µl - -

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295,00 €
 
Protein function: Double-strand break (DSB) repair protein involved in response to DNA damage,... mehr
Produktinformationen "Anti-TP53BP1"
Protein function: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)- mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR. In contrast, it is not required for classic NHEJ and V(D)J recombination. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). [The UniProt Consortium]
Schlagworte: Anti-TP53-binding protein 1, Anti-53BP1, Anti-p53-binding protein 1, Anti-p53BP1, TP53BP1 Antibody
Hersteller: Absea
Hersteller-Nr: OC-258

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Mixed
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Recombinant human TP53BP1
Format: Solution

Handhabung & Sicherheit

Lagerung: -20°C (avoid repeat freezing and thawing cycles)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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