Anti-TLR9 (Toll Like Receptor 9, CD289)

Anti-TLR9 (Toll Like Receptor 9, CD289)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
T8050-97C.100 100 µg - -

3 - 19 Werktage*

962,00 €
 
TLR9 is a 145-150kD member of the Toll-like receptor family of molecules. It is expressed by... mehr
Produktinformationen "Anti-TLR9 (Toll Like Receptor 9, CD289)"
TLR9 is a 145-150kD member of the Toll-like receptor family of molecules. It is expressed by colonic epithelium, CD123+ plasmacytoid dendritic cells, and transitional B cells, and responds to unmethylated DNA CpG motifs that exhibit either a GTCGTT sequence (in human), or a GACGTT sequence (in mouse). TLR9 is found in the ER, and translocates to either the cell membrane, or to lysosomes where it binds bacterial DNA. Precursor human TLR9 is a type I transmembrane protein 1032aa in length. It possesses a 793aa extracellular region that contains 26 LRRs (aa26-818), plus a 193aa cytoplasmic domain. The full-length 150kD form is suggested to be ligand-binding but nonsignaling. The active form is believed to be an 80kD cleavage product found in the endosome compartment. There are multiple splice forms. One contains a deletion of aa2-16, a second possesses an alternate start site at aa58, while a third and fourth show alternative start sites aa23 and 24 upstream of the standard site. Over aa64-189, human TLR9 shares 76aa identity with mouse TLR9. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 2.5ug labels 10e6 cells, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: Anti-Toll-like receptor 9
Hersteller: United States Biological
Hersteller-Nr: T8050-97C

Eigenschaften

Anwendung: FC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Sheep
Spezies-Reaktivität: human
Immunogen: Recombinant corresponding to aa64-189 from human TLR9 expressed in E. coli (Q9NR96).
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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