Anti-TLR3 (Clone: ABM15D5)-FITC conjugated

Anti-TLR3 (Clone: ABM15D5)-FITC conjugated
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-10-3004-F-25 25 µg -

3 - 11 Werktage*

149,00 €
ABE-10-3004-F-100 100 µg -

3 - 11 Werktage*

418,00 €
 
TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response.... mehr
Produktinformationen "Anti-TLR3 (Clone: ABM15D5)-FITC conjugated"
TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages. Protein function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. [The UniProt Consortium]
Schlagworte: Anti-TLR3, Anti-CD283, Anti-Toll-like receptor 3, Monoclonal Antibody to TLR3 (Clone: ABM15D5)-FITC conjugated
Hersteller: Abeomics
Hersteller-Nr: 10-3004-F

Eigenschaften

Anwendung: FC
Antikörper-Typ: Monoclonal
Klon: ABM15D5
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: A partial length recombinant TLR3 protein (amino acids 25-370) was used as the immunogen for this antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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