Anti-STING

Stimulator of Interferon Genes (STING) is a component of the innate immune response. STING binds to cyclic dinucleotides, which are bacterial second messengers. Recognition of cyclic-di-GMP (c-di-GMP), c-di-AMP, or c-GMP-AMP leads to activation of NF-kappaB and transcription of immunomodulatory genes, including type I interferon (IFN). Loss of STING regulation contributes to autoimmune disorders through increased IFN activity. The gene for STING is mutated in the mouse strain Goldenticket, which consequently lacks a type I IFN response to Listeria infection. Activation of STING by the flavonoid 5,6-dimethylxanthenone-4-acetic acid (DMXAA, Cay-14617) has been shown to kill solid tumors in mice, but the binding site of DMXAA is not conserved in human STING.Synonyms: Endoplasmic Reticulum Interferon Stimulator, ERIS, Mediator of IRF3 Activation, MITA, MPYS, Stimulator of Interferon Genes, TMEM173, Transmembrane Protein 173. Immunogen: Human recombinant STING (Item No. 15139). Formulation: (Request formulation change), 250 µg of Protein A-purified polyclonal antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: ELISA, IP, and WB.