Anti-sPLA2 (human Type IIA) (Clone SCACC353)

Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position yielding a free fatty acid and a lysophospholipid. The release of arachidonic acid from membrane phospholipids by PLA2 is believed to be a key step in the control of eicosanoid production within the cell. Human synovial sPLA2 is a secreted, 14 kDa protein which is dependent on Ca2+ for optimal activity. Human synovial sPLA2 is 79% homologous to rat platelet and mouse type II sPLA2s.Synonyms: Secretory Phospholipase A2 (human synovial). Immunogen: Human recombinant synovial sPLA2 Type IIA. Clone Designation: SCACC353. Formulation: (Request formulation change), 350 ug of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol, 0.1% BSA and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: IP, WB. Cross Reactivity: (-) Bee venom SPLA2 (Type III), (-) Human sPLA2 (Type V). UniProt Accession #: P14555. Origin: Animal/Mouse.