Anti-Sphingosine Kinase 1

SPHK 1 catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate. This reaction plays an important role in determining cell proliferation versus cell death. SPHK 1 is found in a wide variety of tissues and cell types including kidney, liver, spleen, heart, platelets, and human tumors. On a cellular level, it is found in the cytosolic and membrane fractions. Based on the amino acid sequence, this protein has a molecular weight of approximately 43 kDa. The observed band at 50 kDa may be explained by some reported post translational modifications.Synonyms: SK 1, SPHK 1, SPK 1. Immunogen: Synthetic peptide from an internal region of human SPHK 1. Formulation: (Request formulation change), Lyophilized peptide affinity-purified antibody. Storage Buffer: TBS, pH 7.4, with 5 mg/ml BSA when reconstituted in 500 µl double distilled water. Host: Rabbit. Applications: ICC and WB, other applications not tested. UniProt Accession #: Q9NYA1 (human). Origin: Animal/Rabbit.