Anti-SIRT5

Anti-SIRT5 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-SIRT5 from human, mouse and rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-SIRT5 from other sources has not been determined. Protein function: NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. [The UniProt Consortium]