Anti-SCN1A/SCN2A/SCN3A/SCN4A/SCN5A/SCN8A/SCN10A/SCN11A (PACO04990)

SCN1A/SCN2A/SCN3A/SCN4A/SCN5A/SCN8A/SCN10A/SCN11A Antibody (PACO04990). Protein function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli. [The UniProt Consortium]