Anti-RON

Anti-RON antibody is directed against human RON. The antibody detects both unphosphorylated and phosphorylated forms of the protein. Anti-RON antibody was purified from rabbit serum by Protein A chromatography and cross adsoption of the GST tag. Cross reactivity with RON from other species has not been determined. RON is a member of the protein kinase superfamily. Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. RON is a heterodimer composed of an ? chain and a ? chain. The ? chain is completely extracellular, whereas the ? chain traverses the cell membrane and contains the intracellular tyrosine kinase and regulatory elements. Anti-RON Antibody is ideal for investigators involved in Cell Signaling, Cancer, Neuroscience and Signal Transduction research.