Anti-Rabbit Polyclonal Antibody to Histone H3

Histone H3 is the core component of nucleosome. It has been implicated in nucleosomes wrap and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Rabbit Anti-Histone H3 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Histone H3 (Swiss Prot: P68431). Protein function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [The UniProt Consortium]